Biocompatibility is a fundamental aspect of dental materials, encompassing the interaction between dental restorations and the living tissues in the oral environment. The biocompatibility of dental materials ensures that they do not provoke adverse reactions or compromise the health of surrounding tissues. This is particularly significant in the context of restorative and prosthetic dentistry, where materials such as composites, ceramics, and metals are routinely used. Rigorous testing and evaluation are employed to assess the biocompatibility of these materials, taking into account factors such as their impact on cellular health, potential toxicity, and immune response. In the realm of dental implants, the biocompatibility of materials plays a pivotal role in osseointegration, influencing the success and longevity of implant-supported restorations. As our understanding of biocompatibility evolves, so does the selection and development of dental materials, ensuring that they not only fulfill their functional roles but also promote the well-being of patients in the long run.