Title: L PRF in implant dentistry: Clinical applications, benefits, and limitations
Abstract:
Background: Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous fibrin matrix used to support healing in implant surgery.
Aim: To review its principal applications, reported benefits, and clinical limitations in implant dentistry.
Overview: This narrative review draws on recent clinical guidance, systematic reviews, and clinical studies covering socket preservation, immediate implant gap management, guided bone regeneration (GBR), sinus floor elevation, peri-implant soft-tissue augmentation, and early implant stability.
Clinical applications and findings: L-PRF may be used as a socket plug or membrane after extraction, around selected immediate implants, and with particulate grafts during GBR. In sinus augmentation, it has been used alone in selected protocols or combined with deproteinized bovine bone mineral (DBBM). A 2025 meta-analysis of five randomized trials involving 140 patients found that adding L-PRF to DBBM increased histologic new-bone formation and reduced residual graft material, but did not significantly improve implant stability quotient (ISQ) at loading. Peri-implant soft-tissue reviews report possible gains in mucosal thickness and keratinized-tissue width with less donor-site morbidity, although esthetic evidence is limited. Findings for immediate implants and early stability are mixed; any ISQ benefit remains uncertain.
Clinical relevance: L-PRF is a practical autologous adjunct that may support early wound healing and graft handling. Use should match the socket and defect anatomy. It is not a universal substitute for bone grafts or mechanically stable membranes when space maintenance is required. Standardized preparation and reporting are essential.
Conclusion: L-PRF has an indication-specific role in regenerative implant procedures. Evidence supports selected early and histologic benefits, but does not establish superior long-term implant survival, marginal bone stability, or esthetics.
