Title: Platelet rich fibrin in implant dentistry: Clinical applications and regenerative potential
Abstract:
Background: Platelet-rich fibrin (PRF) is a second-generation autologous platelet concentrate widely used in implant dentistry due to its regenerative potential. By releasing growth factors and providing a fibrin matrix, PRF promotes both bone and soft tissue healing. Despite its increasing popularity, the clinical benefits of PRF remain a subject of ongoing debate.
Objective: To evaluate the biological properties and clinical applications of PRF in implant dentistry, with a focus on its role in enhancing tissue regeneration and improving clinical outcomes.
Materials and Methods: This study is based on the clinical experience of the Department of Oral Implantology at the Central Military Hospital of Algiers, supported by clinical cases illustrating various applications of PRF. Different protocols, including leukocyte- and platelet-rich fibrin (L-PRF) and injectable PRF (i-PRF), were used in pre-implant and implant procedures. Indications included sinus floor elevation, post-extraction socket management, guided bone regeneration, and immediate implant placement. PRF was used alone or in combination with bone graft materials.
Results: Clinical observations demonstrate that PRF enhances soft tissue healing and contributes to improved bone regeneration. Its use in sinus lift procedures may reduce healing time, while in immediate implant placement, PRF appears to improve primary stability and reduce marginal bone resorption. In guided bone regeneration, PRF acts as a biologically active scaffold, promoting angiogenesis and cell migration. Injectable PRF (i-PRF) shows promising results in stimulating fibroblast activity and growth factor release. However, variability in preparation protocols and the lack of standardized clinical studies remain limitations.
Conclusion: PRF represents a promising, cost-effective, and autologous biomaterial in implant dentistry. Its application may enhance healing and support tissue regeneration, particularly when combined with conventional grafting techniques. Nevertheless, further well-designed clinical studies are required to validate its long-term efficacy and standardize its use in daily practice.
