Title: Personalized and Precision Medicine (PPM) as a transformative healthcare model via biodesign inspired translational applications to secure human healthcare and biosafety
Abstract:
There is a strong worldwide need now to secure a process of re-shaping tomorrow’s healthcare whilst doing IT today. The link that might drastically improve the healthcare services on one hand and to significantly optimize the efficacy of treatment for those who had fallen ill and for persons-at-risk is Personalized and Precision Medicine (PPM). PPM as being the Grand Challenge to forecast, to predict and to prevent is rooted in a Big and a New Science generated by the achievements of: (i) systems biology and OMICS technologies, (ii) integrative medicine and (iii) translational research and applications. To achieve the implementation of PPM concept into the daily clinical practice, it is necessary to create a principally new strategy based upon subclinical and/or predictive recognition of biomarkers long before the illness clinically manifests itself. Genomics is considered to be a set of the major and unique OMICS biomarkers and thus the molecular tools to probe genome for its quality and now even be tested to predict risks of the chronification and thus of disabling, whilst illustrating the signs or risks of hidden (latent) but precision pathology. In this context, a traditional approach to dental and oral cavity care is no longer sufficient. Armed with the genetic information, the dentist and hygienist can recommend: (i) increased Frequency of Visits to keep bacterial levels at an absolute minimum, (ii) individualized and Targeted Home Care: may include specific antimicrobial mouth rinses, high-quality electric toothbrushes, or prescription-strength toothpaste to give a client an edge in the daily fight against plaque, (iv) nutritional and Lifestyle Counselling: since genetics influences inflammation, personalized dietary changes focused on food design-driven anti-inflammatory foods can play a supportive role in managing the gum health.
Understanding individualized genetic makeup is a powerful step toward a lifetime of oral health. It transforms the dental care conversation from one of generic advice to one of PPM-guided strategy. By identifying the individualized genetic risk pre-early, the patient or pre-illness person-at-risk can take decisive action to prevent problems before they start, avoiding the significant risks of untreated periodontal disease, which can range from tooth loss to impacts on the systemic health. Advances in multi-OMICS and Imaging technologies integrated with bioinformatics tools and data bioanalytics have contributed to the development of modern diagnostics and targeted therapies in PPM-guided dentistry. The latter may be able to potentially shift the burden of disease and improve the oral health, thus, improving overall health. The emergence of advanced technologies - such as: (i) digital imaging, (ii) dental design/computer-aided manufacturing (CAD/CAM) digital workflow in restorative dentistry, (iii) Intraoral scanners in dentistry and (iv) bioprinting technologies and 3D printing in dentistry offers transformative potential across the full spectrum of PPM-guided dentistry, including restorative, prosthodontic, orthodontic, endodontic, and surgical practices.
Contributions may also explore interdisciplinary collaborations, educational strategies for digital skill development, and future trends in PPM-guided technology-driven dental care. Submissions that bridge the gap between biodesign-driven innovation and clinical application, particularly translational or implementation research, are of particular interest. By gathering diverse perspectives and evidence, this collection aims to advance the field of PPM-guided dentistry and inform best practices for technology adoption in restorative, prosthodontic, orthodontic, surgical, and general dental practice. With the right technology, dentists can provide complete, yet gentler care even when treating areas deep in the patients’ mouths. The right precision technology not only ensures that patients receive the best care but also provides patients with greater comfort while undergoing treatment. For patients who find it stressful to undergo dental treatment, PPM-guided dentistry makes the process much more comfortable. By coordinating with other healthcare providers and tailoring care to the patient’s medical context, dentists can help improve not just oral health, but overall wellness. In this context, previous educational paradigms will not facilitate the expansion of PPM-guided dentistry. Successful implementation of PPM requires changes in practice patterns and management strategies for oral health professionals and dictates that PPM-guided dentistry should be taught in the curriculum and impact clinical practice in the future.
PPM calls for a transdisciplinary approach, and considerations for how best to develop innovation frameworks to support safe and effective deployment of the new enabling diagnostic and therapeutic technologies not to treat but to get cured!!! Indeed, the health technologies of the next-step generation and their applications can help strengthen and triangulate the Attendant evidentiary base for PPM whilst securing the ideal health and wellness!!!
