Synergistic effect of platelet rich plasma with hyaluronic acid injection following arthrocentesis to reduce pain and improve function in TMJ osteoarthritis

Title: Synergistic effect of platelet rich plasma with hyaluronic acid injection following arthrocentesis to reduce pain and improve function in TMJ osteoarthritis

Abstract:

Aim of investigation: This study aimed to deter mine whether injection of PRP+HA following arthrocentesis reduces pain and improves maximum incisal opening.
Methods: This was a single-blind, prospective, randomized control study. The patients were selected based on the Hegab classification: Group I: patients treated with arthrocentesis followed by a single PRP injection; Group II (Control): patients treated with arthrocentesis followed by a single HA injection; and Group III: patients treated with arthrocentesis followed by a single PRP+HA combination injection. The primary predictor variable was the medication used for injection. The primary outcome variables were the maximum voluntary mouth opening and pain index scores. The secondary outcome variable was joint sounds. All outcome variables were assessed and compared among the three groups at baseline and at 1-, 3-, 6-, and 12-month intervals. Other variables, including patients’ age and sex, were evaluated in relation to the patient outcomes.
Results: Injecting PRP+HA showed statistically significant improvement in the primary and secondary treatment out comes over PRP or HA injection throughout the study period.
Conclusions: Injection of PRP+HA following arthrocentesis had significant long-term clinical efficacy regarding pain relief that considered the main concern of both the patient and clinician.

Biography:

Dr. Ayman Hegab is a Clinical Associate Professor of Oral & Maxillofacial Surgery, Faculty of Dental Medicine. Al-Azhar University. Cairo. Egypt.Editor: Journal of Dental Health, Oral Disorders & Therapy. Editor: Journal of Oral Hygiene & Health OMICS Group (USA). Editor: Journal of dentistry and orofacial surgery. Editor:International Journal of Oral and Craniofacial Science. Reviewer: Journal of Cancer and Tumor International. Reviewer: Journal of Dentistry OMICS Group (USA). Reviewer: Open Journal Stomatology (USA). Reviewer: British Journal of Medicine and Medical Research (UK). Member of Egyptian Dental Association.Member of Egyptian Society of Oral & Maxillofacial Surgeon.Doctor, s Degree (PhD) of Oral & Maxillofacial Surgery focuses on the Alveolar Cleft, Faculty of Dental Medicine. Al-Azhar University. Cairo. February May 2007. Master’s Degree (MSc) of Oral & Maxillofacial Surgery focuses on the TMJ Surgeries, Faculty of Dental Medicine. Al-Azhar University. Cairo. December 2003. Bachelor Degree (BDS) of Dental Medicine & Oral Surgery, Faculty of Dental Medicine, Al-Azhar University, Cairo. May 1997. He has the privilege to design and introduce Tooth-Borne, CustomMade Distraction Device for closure of the alveolar cleft which is approved by American Journal of Oral and Maxillofacial surgery (Hegab Alveolar Distraction Device). Also, He has the privilege design and introduce split acrylic splint for treatment of pediatric mandibular fracture which approved by the British journal of Oral and Maxillofacial Surgery (Hegab Pediatric Mandibular FractureDevice). He has over 20 Publication in peer reviewed journals. He is one of AEEDC Young Researcher Award Participants for 2012 & 2013. He was Speaker in many of the international conferences in USA, Qatar and UAE.