Title: Pregnancy outcome of anti thyroid drugs (NEOMARCAZOLE) on developing jaw an array of clinical & radiographic findings
Hyperthyroidism is an endocrinal disorder caused by abnormal excessive production of thyroid hormone, characterised by intolerance to heat, emotional instability, tremors, increased appetite, and weight loss. Hypertension, sinus tachycardia, increased cardiac output & heart murmurs. Various antithyroid drugs are used for the treatment. Neomercazole is one among them. We present a case of a 17-year-old boy with a chief complain of exfoliation of upper front teeth 1 day back. History of present illness revealed that he lost his upper front teeth while he was having chicken sticks. Both the teeth were mobile before exfoliation. There was no history of trauma. His medical history was insignificant. Family history revealed that the patient’s mother was hyperthyroid since past 30 years and on antithyroid medication. On further eliciting the pregnancy history of patient’s mother, she revealed that she was having Neomercazole during her first trimester unknowingly, and later discontinued the medicines on her gynaecologist instructions. She also reported of multiple abortions during that period. On general physical examination the patient is tall statured 5 feet 11 inches, thin physique, with all vital signs in normal range. There was no abnormality detected on extraoral examination. On intraoral examination there was 11, 21 missing. There was generalised periodontal pockets and mobility of teeth. On radiographic examination there was multiple retained deciduous teeth and all molars with short roots and open apices and tapered lingually, atypical presentation of tooth morphology, altered crown- root ratio. There was a radiolucent lesion in between 12 and 14. 13 was missing. Later, CBCT was done and there was big lesion involving maxilla. The lesion was operated and sent for histopathological examination and the results are awaiting.
Conclusion: There are little cases reported in the literature, some goes undetected, thus a detail knowledge and awareness about the hormonal impact on maxillofacial region is required. Combined long-term research with collaboration of endocrinologist and dentist can improve the quality of life of an individual.