Introduction: Interactions between systemic and oral diseases have been investigated in many contexts. There is evidence to suggest a correlation between systemic disease and endodontic pathology. If these were proven to be correct, clinicians could ascertain essential information regarding the prognosis of endodontic treatment by looking at a patient’s medical history.
Discussion: This paper reviews the available evidence on whether systemic diseases including cardiovascular disease, diabetes mellitus, HIV and the use of bisphosphonates can impact the success of endodontic treatment outcomes.
Conclusions: There is currently a lack of conclusive evidence to support links between systemic diseases on endodontic outcomes. This area of research requires further attention.
Clinical Relevance: If systemic disease is found to impact upon non-surgical endodontic treatment outcomes, dentists could learn essential information regarding the prognosis of endodontic treatment by looking at a patient’s medical history.