Introduction: The Oral Squamous Cell carcinoma (OSCC) is the most prevalent cancer in the oral cavity with the highest mortality rate. Anticancer drugs like Cisplatin are used extensively to treat OSCC but are known to have serious side effects. Hence there exists a pressing need to explore combination therapies. Combination therapies of cisplatin with other drugs can reduce the dose of Cisplatin, and concomitant side effects.
Aim: The aim of the current study is to investigate the curative properties of polyphenols available in traditional green tea in combination with cisplatin in treatment of OSCC.
Materials and Methods: Human OSCC cell line was established under controlled in-vitro micro environment and the cell optical density was recorded following which the cell survival rates were calculated for Cisplatin, Epigallocatechin gallate (EGCG) and their combinations.
Results and Conclusions: The anti-carcinogenic property of Cisplatin in combination with EGCG has resulted in appreciable reduction in the cell survival. The effective combination is 1µg/ml of Cisplatin with 150µg/ml EGCG over duration of 72 hours results in an optimal reduction of survival. The alternative cancer treatment therapy such as green tea does not replace totally the available conventional treatment strategies. The investigation proves that these alternative treatments can substantially reduce the dosages / period of treatment by conventional chemotherapy treatment, the cancer patients would be benefited to a very large extent. It is also important to note that these alternate methods of treatment have no side effects. Thus, helping the patient to recover fast.