Maxillofacial Prosthetic Rehabilitation is the emerging field in Dentistry. Prosthodontic rehabilitation of patient with maxillofacial defects depend on extend of the defect after resection. Rehabilitation of such patient is challenging in our context because of patient awareness, availability of materials and good technical skill. The prime concern during rehabilitation of patient with maxillofacial defects is to have Prosthesis with functional, esthetical, and psychological acceptance. Retention, support, and masticatory efficiency of the prosthesis are few criteria to be fulfilled but difficult to achieve according to clinical variations. Good co-ordination with maxillofacial surgery team will help to maintain quality of work to improve the quality of life. Prosthodontic can assist the surgeon at the time of surgery to improve the prosthodontic prognosis of definite prosthesis.