Paracoccidioides brasiliensis infection is a clinical occurrence that has drawn attention to the health services in their specialties by having increased the number of cases in recent times. Among the listed specialties is dentistry, where some findings of the case are presented in this paper. A 56-year-old woman, smoker, visited the dental health service of a town located in the South of Brazil, without exposure to any factor that can conduce to the development of the disease. The present study describes the occurrence that was elucidated with the use of the histopathological examination as a diagnostic tool for fungal infection in patients immunosuppressed or not. The case has presented by a main lesion, painless ulcer in the gingiva between the lower incisors, the furrow fund, with a duration of 15 days. After the diagnosis of Paracoccidiodomycosis, patient was referred to an infectious physician who, through imaging exams, detected outbreaks of the infection in the lungs. The patient started the treatment and is being kept in control. As conclusion we can affirm that the early diagnosis of this disease is essential to conduce to appropriate therapy, which will contributes to avoid serious sequelae or even death, when used in conjunction with other professionals, applying the science of interdisciplinarity, it is possible to enhance diagnostic tools, guaranteeing a better use of the treatment possibilities, accelerating the healing process and consequently giving the patient the functionality of the affected tissues and quality of life.