Title: The modification of the environment as a key to success in bone regenerative therapy
Abstract:
Environmental adaptation allowed the evolution and therefore the prosecution of life on Earth. In 2005, Kendall Powell on Nature journal introduced an important concept for both the retrieval and the study and developing of stem cells, in different tissues of our organism: the ECOLOGIC NICHE. Thinking about stem cells in isolation become important, it could be productive thinking about an individual component of a bigger system, more complex; actually it is falsely simplified. Another concept is linked to this one; it was introduced by Blau in 2001, who said that the modification of the environment plays a significant role in the differentiation of multipotent stem cells. The aim of the study is to evaluate the influence of the environmental modification histologically, using inducible solution in bone healing. In this clinical-histological study were selected 6 patients in good health, with an age between 35 to 58, 4 male and 2 female, which needed the extraction of at least 2 teeth. All patients accepted a therapeutic plan, which included the implant placement in order to solve their partially edentulous. In one dental alveolus was placed a heterologous biomaterial (AD bone®) blended with normal saline. In the second alveolus, the biomaterial was blended with inducible solution. After 60 days, during the reopening phase due to a previous implant placement, it was taken a sample with a milling cutter trephine 2mm for histological examination at the Department of Anatomy at Brescia University. The authors tried to demonstrate how there is no need to place more stem cells in a bone loss zone in order to get it better, but an environmental modification is sufficient to improve it.
