8th Edition of International Conference on Dentistry
and Oral Health

August 24-26, 2023 | Virtual Event

August 24-26, 2023 | Online Event
ICDO 2017

Qian Ren

Qian Ren, Speaker at Dentistry Congress
Beijing Stomatology Hospital, China
Title: Developing tissue engineered models of early invasive oral squamous cell carcinoma: a preliminary study

Abstract:

Oral squamous cell carcinoma(OSCC) is the most common oral malignancy. A large number of studies have investigated into the mechanisms of carcinogenesis and progression, but very few new interventions based on these researches have been put into clinical practices. It is partially due to the limitations of previous experimental systems. Recently, the tissue engineering technology provides a new approach for cancer research. 
However, tumor and the surrounding tumor stroma co-evolve at all times, according to the models built by other researchers by now, the pathological feature indicated by these models could only reflect early staged-tumor invasion. The reactive stroma at early invasive stage differs from lamina propria of normal oral mucosa and the genuine tumor stroma. Actually, it imitates the interface zone at the invasive front of OSCC. So theoretically, the early invasive OSCC models adopting interface zone fibroblasts as stroma cells can mimic the in vivo pathological mechanisms of OSCC more accurately than normal fibroblasts from oral mucosa and cancer-associated fibroblasts from tumor stroma. 

Biography:

Education:
DDS, West China School of Stomatology, Sichuan University,2013
BDS, West China School of Stomatology, Sichuan University,2010

Scientific background:
As project manager:
1. The effect of FAP-mediated extracellular matrix remodeling on the recruitment of cancer surrounding fibroblasts. Funded by Beijing Natural Science Foundation.
2. The role of “ECM-FAP-TGFβ axis” in regulating OSCC extracellular remodeling and CAFs metabolic reprogramming. Funded by Beijing Stomatology Hospital Foundation.
As chief investigator:
1. The time phase characteristics of recruitment and differentiation of the surrounding fibroblasts in oral cancer and regulatory mechanism. Funded by National Natural Science Foundation of China.
2. Association of Helicobacter pylori infection with severity of erosive oral lichen planus. Funded by Beijing Municipal Science & Technology Commission.

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