Title: Developing tissue engineered models of early invasive oral squamous cell carcinoma: a preliminary study
Oral squamous cell carcinoma(OSCC) is the most common oral malignancy. A large number of studies have investigated into the mechanisms of carcinogenesis and progression, but very few new interventions based on these researches have been put into clinical practices. It is partially due to the limitations of previous experimental systems. Recently, the tissue engineering technology provides a new approach for cancer research.
However, tumor and the surrounding tumor stroma co-evolve at all times, according to the models built by other researchers by now, the pathological feature indicated by these models could only reflect early staged-tumor invasion. The reactive stroma at early invasive stage differs from lamina propria of normal oral mucosa and the genuine tumor stroma. Actually, it imitates the interface zone at the invasive front of OSCC. So theoretically, the early invasive OSCC models adopting interface zone fibroblasts as stroma cells can mimic the in vivo pathological mechanisms of OSCC more accurately than normal fibroblasts from oral mucosa and cancer-associated fibroblasts from tumor stroma.