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Sandra Lopez Verdin

potential speaker for international dental conferences 2017 - Sandra Lopez Verdin

Title: Molecular aspects of oral cancer

Sandra Lopez Verdin

Guadalajara University, Mexico

Biography

I started my studies at the University of Guadalajara in 1999 and I graduated from the bachelor's degree in dentist surgeon in 2004. For 2007 I was admitted to the specialty of pathology and oral medicine at the University of greater prestige in this area, the Universidad Autonoma Metropolitana-Xochimilco. Return to my hometown, Guadalajara, I was invited to study the master's degree in Gerontology where I participated in a book with the chapter of oral cancer. At the same time, I developed the ability to write articles by reporting cases of oral pathology, especially oral cancer. In 2010 I was accepted as a guest researcher at the University of Guadalajara, where I could managed to publish original Works. For 2012 I was accepted in the same university, in the PhD of Molecular Biology in Medicine of which I graduated with the thesis: Expression of the CDH1 / E-cadherin gene, soluble transmembrane and E-cadherin in squamous cell carcinoma of the head and neck. I am currently a research professor at the University of Guadalajara where I teach classes in Molecular Biology, Pathology and Genomic Medicine.

Abstract

Since the definition of oral cancer, the continuous search for diagnostic tools that can predict the behavior of cancer, as well as determine its evolution during treatment, has been a topic of interest in the world of research. At present, oral cancer can first be intuited by certain clinical features, white or red patches, ulcerated tumor elevations or ulcers that do not tend to heal. The confirmatory diagnosis is by histopathology, but the problem is that most of the time it is diagnosed at advanced stages when neoplastic cells have invaded the adjacent connective tissue with the ability to do metastasis. Histopathological analysis based on tumor differentiation was once believed to be related to the aggressiveness of the tumor, however, there are studies that report well differentiated tumors that have generated metastasis.

The next tool that has been widely used is immunohistochemistry, but has not yet managed to position itself as a technique that helps in the direction of treatment, as it has been in breast cancer with the her2 protein

Molecular technology tools have aimed at early diagnosis as well as predicting tumor aggressiveness from the perspective of "omic" sciences. For what is discussed What are the advantages or disadvantages of applying this technology? Which of the "omics" sciences proposes the molecular marker with greater fidelity and accessibility for those who develop the clinical profession? At present what is the diagnostic tool most trusted by dentists for the recognition and diagnosis of the disease?